A modern female doctor's soul traverses into the 180-jin illegitimate daughter of the Prime Minister's Manor, Su Qingyan. After Prince Jing, Xiao Jingyuan, annuls their engagement, she publicly counter-annuls him. Relying on her exquisite medical skills, she saves her grandmother, resolves a plague, wins the Empress Dowager's appreciation, exposes her stepmother's poisoning plot, uncovers the imperial family's identity background, successfully detoxifies and slims down, teams up with Xiao Jingyuan to break the deadlock, and ultimately practices medicine to save the world, reaping a fulfilling love.