In the chaotic times of the Republic era, viruses ran rampant, and Jiangling fell. To save his childhood sweetheart Song Yuening, Gu Xingyao was infected and severely injured, sent overseas, only to wake up having forgotten the person he most wanted to protect. Losing her homeland, Song Yuening fled with her younger sister and survivors to Lankuan, growing from a wealthy young lady into a woman daring to fight for everyone's survival under the silent protection of General Si Chenye. On the other side of the ocean, Gu Xingyao studied medicine and sought medicine, desperately fighting to reclaim his memory and the way back home. Some profited from medicine and ship berths, while others paid everything for an unspoken love. When the two finally reunited, what lay before them was the life-or-death choice between their beloved and the people of an entire city.