In the first year of the apocalyptic catastrophe, virologist Rong Yu sacrifices herself in a heroic explosion within a sealed-off zone to kill the ultimate mutant and protect humanity and her young son. Unexpectedly, her soul travels through time and is reborn seventy years later, in a new era, possessing the body of an 18-year-old wasteland girl who is despised by everyone. The son she once risked her life to protect has now grown old and fallen gravely ill, yet he leads the Ji family and holds humanity's fate in his hands. Her two exceptional great-grandsons also occupy central positions in the safe zone. Armed with the knowledge of her past life and an unwavering devotion to her bloodline, Rong Yu sheds her identity as an ordinary, useless girl and makes a powerful comeback. In her youthful new body, she once again takes up the mission of protecting a bloodline spanning a century and the hope of humanity.