Han Shuo and his teammates struggle to survive in a doomsday overrun by zombies. They accidentally discover the secret of genetic evolution, enter an underground research institute, and become genetic humans. However, as the truth surfaces, the zombie king turns out to be the director's former apprentice, who escaped after being modified into an experimental source body and released the ice crystal virus to create this catastrophe. His heart's black blood is the key to ending the apocalypse. The research institute is destroyed by the zombie tide, and Han Shuo leads his companions to evacuate through the escape route, bearing the mission of saving humanity and embarking on the journey to find the antidote.