In the medicine city of the Republic of China era, Qin Yong, a pharmacy owner, was wrongly accused and fell into heavy debt, forcing him to travel far to Nanyang to make a living. Before parting, he pledged a reunion promise with his daughter A Tang using a red rope. Soon, false news of a shipwreck in Nanyang arrived, and his greedy younger sister Qin Ying embezzled the relief funds. Fortunately, A Tang was taken in by a medical clinic, where she displayed extraordinary medical talent, saving A Wu, the warlord's son, and the two forged a deep bond.