On the road of fleeing from famine, modern medical student Ye Qizhen transmigrates into a book and becomes Ye Zhenzhen, binding the Divine Doctor System. Along the refugee road, from treating high-fever children to cracking the plague and overcoming smallpox, she step by step counterattacks from a refugee village girl to a generation of divine doctors. Standing by her medical skills and helping the world with a benevolent heart, she carves out her own path in troubled times, finally saving lives and healing the wounded, protecting the people of a region.