Shen Nanxing, a genius doctor from the 22nd century, transmigrates into the body of an overweight, unattractive young woman who was poisoned by her stepmother and half-sister and rejected by the Crown Prince, who breaks off their engagement. After binding herself to a medical system, she publicly divorces her fiancé, earns points by humiliating her enemies, cures her poisoning, and transforms her appearance, using her extraordinary medical skills to rise to prominence in the capital. By chance, she saves the Ninth Imperial Uncle, Murong Yuan, who suffers from a severe cold poison. The two go from bickering adversaries to lovers who heal each other's wounds. Facing schemes within the household and conspiracies over imperial power, they join forces to expose the poison plots and restore order. In the end, they ascend to the throne as Emperor and Empress, ushering in a golden age of medicine.