Mu Qingli, the Empress of Myriad Realms, was conspired against and severely injured by her own sisters. She took refuge in the Valley of the Medicine King to cultivate and heal her injuries, but was attacked and fell within the valley. A wisp of remnant soul was reborn, possessing Su Qingli, the bullied concubine-born daughter of the Su Family, an affiliate of the Xuantian Sect. Armed with the alchemical, venomous, and medicinal secret arts taught by the Medicine King, combined with the martial prowess of a former empress and imperial clan secret techniques, she fights back against her biased family, neutralizes lethal crises, and on her way to the immortal sect assessment, encounters Chu Mochen, the reincarnated Emperor whose cultivation has been sealed by a curse. Ultimately, she breaks free from her original shackles, ascends once again to the peak of the myriad realms, and reaps the supreme supreme dao companion and the ultimate grand Dao.