Yun Jiawan, heir to the Lingshu Medical Valley, descends the mountain on her master's orders to break off an arranged marriage. However, Su Lingshu, the matriarch of the Dingyuan Marquis household, takes the opportunity to betroth her to Shen Zhiyu, the eldest legitimate son who has been paralyzed by poison. Guided by a healer's compassion, Yun Jiawan steps in to save him, only to become entangled in a conspiracy to seize the marquisate. She also uncovers the truth behind the massacre of the Yuehua Medical Valley twenty years ago. Working together, the two overcome one crisis after another, from internal power struggles within the marquis household to political turmoil at court. In the end, they eliminate the mastermind, Prince Duan, and retreat to the Medical Valley, where they devote themselves to healing and helping the world.