Newly crowned top scholar Gu Changsheng transmigrates to the Great Yan Dynasty and activates the Heaven's Will Trouble-Making System. Using the Ten Thousand Poisons Manual, he cultivates an impervious-to-all-poisons constitution and takes the initiative to ask for the hand in marriage of Li Cangyue, the powerful Grand Princess who oversees the imperial government. He uses extraordinary techniques to keep the Emperor, who has been struck by a deadly poison, alive; seizes the opportunity presented by a locust plague to launch Green Cloud Pearl and amass a fortune; and successively defeats the Second Prince, the poison strategist Wenren Mu, and the powerful aristocratic clans. In the end, he assists Li Cangyue in seizing the imperial throne, enjoying one satisfying triumph after another while living off his powerful bride.