Su Qingqing, a surgeon, transmigrates into the body of a fake heiress of a marquis's household. Her story begins with a substitute marriage, as she takes the severely injured and voiceless deposed Crown Prince, Qi Jin, into exile in the northwest. Along the three-thousand-mile journey, she uses her extraordinary Chinese and Western medical skills and her portable supply system to save lives, heal the wounded, and overcome one crisis after another. She also lovingly cares for her fallen husband, treating his injuries and illnesses. From mutual suspicion, the two gradually come to trust each other with their lives. Upon reaching the bitterly cold place of exile, Su Qingqing cultivates farmland, develops infrastructure, improves people's livelihoods, and establishes workshops. As her businesses flourish, she uses her own abilities to lead the deposed Crown Prince toward an increasingly prosperous life.