Chen Wenyu, a renowned physician of the Great Liang, travels throughout the nine provinces, compiling a medical compendium to save lives. Her extraordinary medical skills earn her the trust of Emperor Xiao Yan, who appoints her to lead the Imperial Medical Academy and promote her medical compendium. Consumed by jealousy, Noble Consort Xiao subjects Chen Wenyu to cruel punishment and schemes to seize her medical work. Fortunately, with the assistance of the Minister of Revenue, Chen Wenyu devises a trap using a false prescription, causing the noble consort to bring disaster upon herself through improper medication and ultimately be demoted. Later, Chen Wenyu travels to the Northern Di to combine the medical practices of the north and south and perfect her compendium. In recognition of her achievements, she is bestowed the title of Female Marquis of Medicine by the Great Liang.