A gamer defeats the ultimate boss, the Peerless Poison Demon, but is suddenly caught in a strange phenomenon and transmigrates to the Miao frontier, where he becomes Lan Yinluo, a disciple of the Ten Thousand Gu Fiend Abyss. The original owner was ambushed, leaving her dantian shattered and her meridians completely severed, turning her into a cripple. After awakening, the protagonist discovers that the Peerless Poison Demon is sealed inside her dantian. She masters the Bone-Melting Art, a cultivation technique that transforms poison and vitality into cultivation power. When her fiancé comes to break off their engagement and humiliate her, she writes a letter of divorce instead. This provokes her enemies into launching a midnight assassination with poisonous Gu. Lan Yinluo uses her technique to kill her attackers, refine their power to break through to a higher cultivation realm, and create poisonous Gu to intimidate the local villagers, all while building up her strength to take revenge on her enemies.