Cross-time company employee Gou Chengcai receives an order from Ming Founder Zhu Yuanzhang and travels far to the Ming Dynasty to treat the critically ill Empress Ma. Amid their medical exchanges, he reveals many future secrets to Zhu Yuanzhang, and also receives a cry for help order from the Yongle Emperor, Zhu Di, taking him to modern times for medical treatment. Spanning two generations of Ming emperors, Gou Chengcai shuttles between ancient and modern times, witnessing both monarchs' deep concern for their country, family, and loved ones, writing a heartwarming and imaginative cross-era story through countless spacetime transactions.