Medical Immortal Gu Beichen, due to an imbalance of true Qi, follows his master's orders to go down the mountain to find a method to resolve it and investigate the truth behind the annihilation of the Gu family. Upon first arriving in Yunzhou, he rescues the attacked Wen Qingyao, confirming that she is the key person he is looking for. Relying on his exquisite medical skills and extraordinary courage, Gu Beichen punishes evil villains, gathers connections, gradually uncovers the truth of the old case, and successively defeats the heavy conspiracies of hostile forces. In the ultimate duel, Gu Beichen breaks through his cultivation realm in a desperate situation, finally clearing his family's name. In the end, Gu Beichen reunites with everyone, the Gu family's reputation is revitalized, and a new chapter begins in Yunzhou.