Shu Yao, the Medicine Sovereign of Yanzhou, is actually an abandoned daughter of the family who was plotted against and pushed off a cliff by her own younger sister five years ago. On the night she fell off the cliff, it happened to be when Qin Yuan, the Qilin Divine Lord, suffered an outbreak of enchanting poison, and the two accidentally became entangled. At the time of Shu Yao's delivery, the demon clan launched a sudden raid; their eldest daughter, Xiao Yan, risked her life to set up a barrier before going missing, leaving Shu Yao to struggle for survival with only her younger daughter, Xiao Miao. Over the five years, Shu Yao treated Xiao Miao for her cold affliction, while Qin Yuan also searched bitterly outside for their eldest daughter, Xiao Yan. Until Shu Yao stepped into the Prince's Mansion to practice medicine, the twin sisters were accidentally swapped, and the twins joined hands to recognize each other, finally untangling the estrangement and mystery between their parents that lasted for five years.