A top modern poison doctor, Shen Jingzhi, transmigrates as an abandoned daughter of the Prime Minister's estate in Great Xuan. Relying on her hardcore modern medical and toxicological skills, she exposes harem political intrigues and hidden plots, cracks the wrongful poisoning case in Qinghe County, breaks the monopoly of nobles on medicine, and seeks a path to survival for ordinary people. Walking side by side with Prince Regent Chu Yuan, she protects all living beings with a healer's benevolent heart, fully displaying the independent and clear-headed backbone of a great heroine.