After an accident, Mu Chun travels back to the third year of the Hongwu era and becomes the adopted son of Emperor Hongwu Zhu Yuanzhang and Empress Ma, while remaining the biological son of Mu Ying. He originally intends to take life easy and enjoy his privileged existence. But seeing how deeply Zhu Yuanzhang, Empress Ma, and the kind-hearted Crown Prince Zhu Biao cherish him, and remembering the tragic fate destined for them in the history books, Mu Chun can no longer sit idly by. Thus, the course of the Ming Dynasty takes an unexpected turn. He opens a medical clinic and gathers medicinal herbs, successfully nursing Empress Ma back to health.