A modern girl skilled in both medicine and poisons has her soul transmigrate into the legitimate daughter of the prime minister who was victimized and buried alive. Escaping from the coffin, she saves the Regent Ye Lijue, who is afflicted with a severe poison. She returns to the prime minister's estate to punish her vicious, scoundrel father, stepmother, and stepsister, and to protect her biological mother, who comes from a wealthy merchant family. For political balance, the emperor bestows her in marriage upon the Regent, who wields power over the court, appears cold and ruthless to outsiders, but dotes on her alone. The two join hands to unravel court conspiracies, struggling to make their mark while sparking numerous hilarious everyday moments, running towards each other wholeheartedly for a lifetime as a devoted pair.