Qiao Yun, the legitimate daughter of the Prime Minister, is framed by her stepmother and half-sister. Her betrothal to the Crown Prince is stolen from her, and she is forced to become a substitute bride, sent to the dreaded Prince Qi's household to bring him good fortune and ward off his illness. Rumor has it that Prince Qi, Shen Jue, is suffering from a deadly poison and has a cold, ruthless temperament. Yet he treats Qiao Yun differently from everyone else. She is the only antidote capable of suppressing his deadly poison and the sole warmth in his otherwise bleak life. United as husband and wife, they settle old scores with the Qiao family, foil the Crown Prince's treasonous schemes, and navigate the political turmoil of the imperial court together, remaining devoted to each other for the rest of their lives.