Feng Qianqian, a modern-day doctor, travels back in time to the Great Zhou Dynasty, where her half-sister poisons and tries to kill her. After miraculously surviving, she masters formidable martial arts and medical skills. Returning to the treacherous Prime Minister's residence, she seeks revenge on her wicked relatives and opens a Divine Physician Hall to heal and save lives. The Seventh Prince, Nangong Li, whom she rescues from a mass grave, assumes the alias Chu Yu. The two develop a deep mutual understanding and join forces to save people, investigate cases, fight political conspiracies, and rescue her persecuted elder brother, facing the trials and tribulations of the world side by side.