Modern nurse Su An'an transmigrates into an ancient famine year, becoming an orphaned peasant girl whose parents are both deceased. Faced with a comatose hunter husband and two frail little buns, she relies on her portable space and spiritual spring pharmacopoeia to reclaim wasteland and farm, build factories and save people, raise children and build a fortune. From saving disaster victims to going to the battlefield, from power struggles to imperial succession, she performs good deeds and makes a comeback all the way, finally surrounded by children and retiring with achievements, hand in hand with her loved one retreating into seclusion in the countryside, one life, one pair, forever together.