Shen Ningyao, a divine physician abandoned by her family, returns one day and becomes Anping Commandery Princess, personally appointed by the Empress Dowager. She kills the impostor who stole her identity and severs all ties with the Shen family before entering the palace to treat the Third Prince, Cheng Jing, who has suffered for years from a chronic cold poison. Together, they uncover the power-grabbing conspiracy of the Noble Consort and the princess, forming an alliance to stand together through life and death as they carefully navigate palace intrigue. After Cheng Jing recovers, he publicly asks for her hand in marriage, and the Empress Dowager forcefully arranges their engagement. On their wedding day, Cheng Jing is appointed Crown Prince. With nowhere left to turn, the Noble Consort launches a palace coup. Shen Ningyao and Cheng Jing join forces to suppress the rebellion. In the end, Cheng Jing ascends the throne as emperor, and Shen Ningyao is named Empress, fulfilling their long-held wish to rule side by side.