Jiang Niannian, an illegitimate daughter, is forced to marry in place of her legitimate elder sister to a battle-hardened prince who is dying from poison. The entire household mocks her as nothing more than a tool for bringing him good fortune. Little do they know that she is a reclusive divine physician whose miraculous needles can cure the deadliest poisons in the world. When the prince is on the brink of death, she saves his life with a single needle and demands 100,000 taels in medical fees. The money-loving, life-preserving divine physician only wants to earn enough silver to run away, but the cold and ruthless prince falls for her and repeatedly blocks her escape. Together, they join forces to expose the royal family members behind the poisoning. What fate awaits them in the end?