After a family upheaval, Pei Yuyan transfers to a middle school in a county town, where he meets Shen Zhiwei. The two become inseparable friends, gradually developing unspoken feelings for each other. After the college entrance examination, Pei Yuyan loses his memory in a car accident and moves abroad, while Shen Zhiwei stays in her hometown to build a career following changes in her family circumstances. Years later, Pei Yuyan returns to China hoping to help an old friend, but unexpectedly becomes entangled with Shen Zhiwei through an arranged marriage, neither realizing the other's true identity. When Pei Yuyan receives treatment at a traditional Chinese medicine clinic, he reunites with Shen Zhiwei. Their feelings gradually rekindle, but he restrains himself because he believes he is already married. After discovering the Huo family's conspiracy, Shen Zhiwei resolves to protect the Gu Family Pharmaceutical Group. The two join forces to investigate and overcome one crisis after another. When Pei Yuyan is injured saving Shen Zhiwei, his memories finally return.