Yun Si, a top modern-day surgeon, dies suddenly and transmigrates into the body of the Princess Consort of Chu, a woman who was forced to give her blood for a year to sustain her husband's beloved woman before dying full of resentment. Her portable medical kit contains surgical scalpels, blood plasma, and penicillin. From the very beginning, she exposes the fraud of using human blood to cure illnesses. The pretentious secondary consort, the fame-seeking miracle doctor, and the incompetent physician who takes credit for others' achievements are each publicly humiliated by her. The scumbag prince Huo Linye goes from demanding her blood to save his beloved to chasing after her and asking where she learned her medical skills. His long road to winning back his wife officially begins. Meanwhile, the powerful Ninth Imperial Uncle, who commands the court and has paralyzed legs, becomes increasingly interested in her.