Gu Nanxing, the legitimate daughter of a century-old medicine shop, returns through rebirth, appearing lazy and checked out, but actually possessing divine medical skills. She outwits her uncle and foreign forces attempting to swallow her family property, and exposes the dark secrets of fake medicine. In her clashes with the cold-faced drug administration special envoy Lu Chenzhou, the two move from opposition to joining hands, jointly guarding the signboard of Derentang and achieving a double fulfillment of career and love.