Modern medical toxicology doctor Rui Jinxi accidentally time-traveled, becoming the notorious, infatuated legitimate daughter of the prime minister's estate in Dayong. At the start, she was framed and collided with Prince Xuan's heir Mo Yunce, and was betrothed by the empress to bind her to this cold-faced powerful official suffering from a strange poison and wearing a mask. Relying on her medical skills and resourcefulness, she tore apart wicked relatives, reorganized the family business, opened a medicinal diet shop, saved lives and healed the wounded, and stepped carefully between the deep courtyard and the imperial court. From initially disliking each other and going tit for tat, the two joined hands to uncover the old case of the imperial mausoleum and the truth of the poisoning, gradually developing romantic feelings amidst the storms, and finally achieving mutual redemption, guarding the country and each other together.