A traditional Chinese medicine major girl, Song Zhiyi, accidentally transmigrates into a historical romance novel, reduced to a wicked original wife who meets a miserable end on the road of exile. Facing Shen Jinghan, the former chief councilor who is heavily injured and unconscious, malicious escort guards, and successive assassinations, she relies on modern pharmacological knowledge to make a comeback in a desperate situation: stitching wounds with bare hands, instantly identifying poisons, devising plans to repel bandits, and struggling for survival all the way. The two hide in a folk medicine shop to secretly investigate the old private salt case, practice medicine and save lives after arriving at the Lingnan settlement to build up their strength, join hands to fight against the evil forces in the imperial court, and launch a desperate counterattack before the ten-day death deadline.