Wang Ye, who has lived in seclusion on Mount Dongyue since childhood, possesses peerless medical skills and cultivation that reaches the heavens. He descends the mountain and travels to Qingzhou to find his wife, Wen Mingzhu. Upon entering the modern city, he brings the dead back to life with his extraordinary golden needles and begins treating patients at Zhengqing Medical Hall. He cures terminal illnesses, unravels Gu poison and sinister magic, and meets a number of women, including Li Zitian, Jiang Nanyan, Yuan Tingxue, Jiang Xingwan, and Bu Qingwu. As his investigation deepens, Wang Ye discovers that a mysterious organization known as the Ten Directions Universe secretly manipulates powerful families and harms innocent people while colluding with Japanese forces to plot against the Nine Provinces. Facing kidnappings, assassinations, and attacks by grandmasters, he wields the Cangslayer Sword to sweep away formidable enemies, recruits the Snow Fox as an undercover ally, and engages in fierce battles against the Crown Prince of the Ten Directions Universe and the Eight-Headed Serpent.