Born in the countryside, Qiao Xi is exceptionally talented and the closed-door disciple of medical authority Cheng Han. To resolve a family crisis, she is forced to take her stepsister's place in a custom to ward off bad luck by marrying Huo Xingzhou, the second young master of the Huo family, who is rumored to have physical disabilities. After marriage, Qiao Xi always remains true to her original intention as a healer, using her medical skills to save people. Trusting and walking hand-in-hand with Huo Xingzhou, together they pierce through heavy layers of mist to uncover the truth of their family backgrounds. In the process of protecting those around them, they reap sincere love and carve out a career of their own.