Shen He is framed by her family and sent into exile in Lingnan in place of her elder sister. Trapped in desperate circumstances, she uses an illustrated guide that allows her to identify plants and trees to search for medicinal herbs in the miasma-filled forest. She develops remedies against poisonous miasma and insect-repellent ointments, gradually building a successful herbal medicine business from nothing. She helps Madam Zhou and her son, while supporting and relying on Xiao Duo, a man burdened with secrets, as they face challenges from all sides. After enduring countless hardships, Shen He protects her business and her little courtyard, refuses to repeat the mistakes of her family's past, and joins hands with Xiao Duo to embrace a new life.