Shen Yan, the cold doctor of Liuyun Town, originally wanted to bury the old affairs of the immortal sect by practicing medicine, but his peace was shattered by a grandfather and granddaughter fleeing with an account book. The old man died mysteriously, and the account book points to the Huiyuan Altar covering three towns. The stubborn girl Yu Qinghe vowed to bring the truth back to the mountain gate, forcing Shen Yan to re-choose between self-exile and saving all people. A storm stirred up by mortal accounts shaking the order of the immortal sect thus begins from the pharmacy.