Since childhood, Lin Fan has studied extraordinary acupuncture and ancient healing techniques under his reclusive master, possessing a Sacred Extreme Yang Physique. He descends the mountain to gather four divine artifacts needed to save his master's life and encounters Li Wan'er, a woman with the Moonlight Yin Physique. With his exceptional medical skills, he repeatedly overcomes crises and exposes the poisoning schemes and business conspiracies of the Lu and Su families and other villains, earning the favor of influential allies. After gathering all four artifacts, he uncovers the truth behind his blood-soaked origins. Using his peerless medical skills, he protects his loved ones, punishes the wicked, finds true love, and becomes a legendary miracle-working physician.