Lin Changge, heir to the Medicine King's Valley, is ordered by her master to descend the mountain and settle her marriage engagement. Outside a hotel, she steps in to save Fu Chenzhou, the wealthiest man in Yunzhou, who is suffering from a mysterious illness. At the engagement ceremony, Gu Mingzhou and Liu Ruyan make things difficult for her, leading to the cancellation of the engagement and the destruction of a medicinal jade pendant that can relieve cold-related ailments. Afterwards, Gu Mingzhou's condition worsens. Lin Changge proposes a treatment plan and agrees on a fee, but Gu Mingzhou refuses to cooperate and is left with lasting health problems. Impressed by her abilities, Fu Chenzhou enters into a partnership with Lin Changge. Together, they care for Fu's mother, research new medicines, and uncover hidden dangers lurking around them. Later, they will travel together to the capital, seeking their masters and investigating the secrets of Lin Changge's origins and past.