Su Xiaotang, a genius military doctor skilled in both modern Chinese and Western medicine, accidentally crosses over into ancient times as the good-for-nothing legitimate daughter of a general's mansion. Tearing off her human skin mask to reveal her true countenance, with her left hand she commands peerless medical and poison arts, and with her right hand she sweeps across all directions with modern weaponry. From the imperial palace of Junlin to the Southern Border battlefield, from the Mobei River to the unification of the three kingdoms, she slaps faces and abuses scumbags all the way, subduing three major factions: the Bloodthirsty Alliance, the Qingfeng Pavilion, and the Netherworld Hall, ultimately ascending to the throne of Empress Regent. Teaming up with the black-bellied and deeply affectionate Prince of the Underworld, Jun Yeming, from cooperation to mutual understanding and love, the two join forces to quell internal rebellion, recover the Southern Border, annihilate the Witch Border, and retrieve her parents, ultimately walking hand in hand as husband and wife, blessed with children, to unite the continent.