Shen Zhiwei, a modern medical doctor, travels back in time and becomes an orphaned girl from a fallen family of imperial physicians. She is forced to treat Xiao Yu, a tyrannical prince. Amid palace intrigues fraught with danger, she uses her exceptional medical skills to save countless lives while becoming entangled in the crown prince's conspiracy to seize the throne and a life-or-death battle against a raging plague. Shen Zhiwei and Xiao Yu form an alliance to fight back, expose the crown prince's conspiracy, and join hands with Su Jin to overcome the crisis. Ultimately, they help restore the dynasty and win love and honor, weaving a legendary tale of a healer's compassion and a love bound by life and death amid the struggle between power and medicine.