Shen Yulou, a modern pediatrician, is accidentally injured by his girlfriend and falls into a coma, only to awaken in the body of a condemned prisoner in the Great Hui Dynasty. Just as the Imperial Noble Consort falls gravely ill after giving birth, he answers the imperial medical summons and enters the palace to treat her. Little does he expect to become entangled in the power struggle between the Empress and the Noble Consort. Relying on his professional medical expertise, he detoxifies and saves a princess, uncovers the truth behind the attempted murder of a prince, and survives one deadly plot after another. Yet he never suspects that the greatest mastermind behind everything is someone closest to the Emperor.