By imperial decree, the daughter of a renowned physician, Su Qingwan, is married off to Xiao Jingyan, the capital's notoriously sickly prince. Everyone in the city expects her to become a widow, but she happily carries her medicine chest into the prince's mansion. In her eyes, he is not a husband but a rare and challenging medical case. On their wedding night, she grabs her husband's wrist to take his pulse; on the very first day of their marriage, she turns the prince's mansion into a medical clinic. Xiao Jingyan mistakes her for an assassin and avoids her like the plague, only to have his heart won over by the bowls of medicine she makes him drink. But when a long-hidden poisoning conspiracy within the mansion finally comes to light, the frail prince reveals his formidable side for the first time to protect her. She cures his illness with her medical skills, and he heals her heart with his unwavering affection.