In his past life, Shen Changqing squandered his family's wealth, watched his mother and younger brother die miserably, and froze to death on a snowy night. Reborn back to the eighteenth day of the twelfth lunar month in the fifteenth year of Sheng'an, he saves his mother, avoids the collapsing roof beam, and completely cuts ties with Qian Laiwang. Afterwards, he goes up the mountain to gather golden dendrobium, becomes an apprentice to veteran military doctor Sun Boyong to learn medicine processing, and opens the Changqing Mountain Goods Store, buying local goods fairly and getting to know Liu Zhiqiu. Anticipating a plague, he hoards medicine and supplies it to the government at fair prices, becoming famous in a single battle. Framed by Qian Laiwang, Fatty Zhu, and Qian Wanjin, he fights back with evidence. Within ten years, he becomes the Medicine King of the Southwest, builds roads, establishes schools, gives back to his hometown, and finally achieves a joyful family reunion.