Princess Xiao Banxi suffered the cruelty of her closest kin who dug out her divine bones, discarding her into the Abyss of Ten Thousand Beasts to perish. Unexpectedly, she carried the soul of an otherworldly agent and Nirvana-reborn using sacred bones. Along the way, she met the red-robed Demonic Supreme Zi Moran, and the two became intertwined in fate. Wearing a red lotus mask and turning into the Ghost Doctor, she mastered medical skills and animal taming to absolute perfection, with her Jing family brother, best friend Fang Mo, and a host of fierce beasts vowing to follow her to the death. An impostor princess usurped the nest, and both the imperial family and the Nangong family owe her blood debts. Step by step, Xiao Banxi plotted, slapping the faces of her enemies and uncovering the mystery of her birth, while settling the score for the bone theft of yesteryear and running towards a mutual redemption with the sickly-charming Demonic Supreme. Amidst a turbulent era, she rules over ten thousand beasts and reclaims everything that rightfully belongs to her.