Su Wan, the descendant of the Divine Doctor Valley, lives in seclusion at Baicao Residence. She encounters Crown Prince Xiao Chengyuan, who is suffering from a strange poison and comes to seek medical treatment. Seeing the jade pendant at his waist and realizing he is the son of her mortal enemy Xu Qingmei, she flatly refuses to treat him. Xu Qingmei, honored as the Empress, was originally the true mastermind behind the massacre of the entire Divine Doctor Valley. She usurped the position of Empress by impersonating Su Wan's aunt. Su Wan is dragged to the execution ground, but relying on the hearts of the common people, she creates an uproar in the golden court, displaying four hundred and eighty-eight coffins from the valley to expose Xu Qingmei's towering crimes. After Xu Qingmei is imprisoned, her accomplice Wen Xingzhi rescues her, holding the poison classic to wreak havoc in the capital and spread a plague of poison. Su Wan takes personal risks to set a trap, captures and kills Wen Xingzhi, and breaks the toxic plague. Her deep hatred is avenged.