Modern traditional Chinese medicine doctor Ye Wushuang transmigrated, driven out heartlessly by the Minister's Mansion with her mother on a stormy night. In crisis, she awakens the Xuhuai Mansion portable medicine field, accompanied by an arrogant black spirit cat, Xuhuai. Disguised as a man, she wanders to Misty Rain Town, coincidentally saving the heavily injured and distressed Prince Huai, Chu Yaotian. Relying on her medical skills, she opens the Xuanhu Hall, cures the sick with miraculous hands, fights cunning merchants and breaks courtyard plots, establishing a firm foothold in the marketplace. The youth secretly gifts her a brocade pouch token, and the two exchange letters by wild geese, secretly developing feelings. The Ye family still refuses to let go of their mother and daughter, crises press closer step by step, and a sudden plague sweeps the turmoil over once again.